Job Description

About Enlaza Therapeutics

Enlaza Therapeutics is a biotech company developing an innovative synthetic biology platform to create a disruptive new class of biologic therapeutics. We are dedicated to the development of these novel therapies to help patients suffering from cancer and other serious diseases.

Role Description:

This position is for a leader in the field with expertise in antibody discovery to help drive our drug discovery programs. We seek an individual that is highly proficient in the strategic aspects of leading immunization and phage campaigns, with specific technical expertise in phage display. This position will work directly on the development of biotherapeutics for serious diseases, and will be involved in the identification, characterization, optimization, and selection of lead molecules for multiple programs. This is an excellent opportunity to work with a motivated and experienced team and interface directly with multiple research groups, including platform engineering, upstream process development, protein sciences, pharmacology, analytics, and leadership. The ideal candidate will be an enthusiastic, motivated, and innovative individual who is excited to lead a dedicated team.

Responsibilities:

• Lead a discovery team of scientists and work closely with other teams, including CMC and upstream process development, to advance sequences to development candidate nomination
• Oversee the design, generation, and execution of naïve antibody/VHH phage display libraries for multiple programs
• Design, initiate, and oversee immunization campaigns at various CROs
• Coordinate the characterization of antibodies/VHHs selected from phage libraries or immunizations, including interpreting, organizing, and presenting the results
• Opportunity to grow into project team leadership roles

Required Skills and Experience:

• PhD in Biochemistry, Bioengineering, or related scientific field, with 8+ years of hands-on experience with antibody discovery
• Extensive hands-on experience with DNA library design and construction, including naïve and affinity maturation libraries
• Understanding of sequence and structure features and properties of multiple antibody formats (traditional mAbs, bi/multi-specifics, scFvs, single domain antibodies, and others)
• Highly collaborative with excellent communication skills
• Ability to work effectively in a fast-paced and cross-functional team environment



Additional Experience Preferred but Not Required:

• Experience with small-format antibody humanization and knowledge of sequence liabilities and developability assessment
• Proficiency with PyMOL, MOE, or similar software for protein structure analysis, protein engineering, and library design

Compensation:

In addition to a competitive compensation package with stock options, the company also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.

Benefits:

• 401(k)
• Dental insurance
• Employee assistance program
• Flexible schedule
• Flexible spending account
• Health insurance
• Life insurance
• Paid time off
• Parental leave
• Relocation assistance
• Retirement plan
• Vision insurance
• Year-end shutdown

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